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MEDICAL ADVISORY BOARD


 
Bruce Spiess, MD, Medical Advisor and Chair of the Medical/Scientific Advisory Committee, is a Professor of Cardiothoracic Anesthesiology and Emergency Medicine at Virginia Commonwealth University. Dr. Spiess is also the Director of Virginia Commonwealth University Resuscitation and Shock Center (VCURES). Outside of Russia, Dr. Spiess has more experience with PFC research than anyone. He has conducted numerous studies in rodents and large animals, primarily swine and has also conducted two clinical trials with PFC emulsions, including a Phase 2a study in TBI and a Phase 2a study in hip replacement surgery. Dr. Spiess has received several multi-million dollar grants from the US Department of Defense to study PFCs in TBI, hemorrhagic shock/resuscitation and decompression sickness; his lab has also done research with PFCs in microcirculation, including Sickle Cell Disease. Dr. Spiess previously served on the Medical/Scientific Advisory Boards for both Alliance Pharmaceuticals and Oxygen Biotherapeutics.

 
Dmitri Bezinover, MD, Medical Advisor, is a Professor of Anesthesiology at Hershey Medical Center. Dr. Bezinover did his medical training at State I.P. Pavlov Medical University (St. Petersburg, Russia). He completed his anesthesiology residency at Havelhohe Hospital (Berlin) and a transplant anesthesia residency at University Clinic, Charite-Virchow (Berlin). Dr. Bezinover has administered Perftoran to patients in Russia and has done several organ preservation/liver transplant studies in rodents with PFC emulsions.
Zachary Franco, MD, PhD, MPH, FCAP is Medical  and Laboratory Director at CSL Plasma.  Prior to medical  school, Dr. Franco was a mathematician with graduate degrees from Harvard and Berkeley. He completed his residency at Texas Tech where he learned about hemoglobin in Jan Simoni's lab.  Dr. Franco is Board certified in clinical  pathology/laboratory medicine and in Blood  banking/transfusion medicine (fellowship trained at Baylor  College of Medicine in Houston).  Dr. Franco has done epidemiological  research in trauma-related massive transfusion protocols.  He has also served on the  College of American Pathologists Resource Committee for  Histocompatibility and Identity Testing.
Krishna Talluri, MD.  Dr. Talluri is a clinical development and safety expert with more than two decades of global experience, including the role of Principal Investigator on several clinical trials in multiple therapeutic areas. She most recently led product development teams at Johnson & Johnson and Talecris Biotherapeutics that included cross-functional groups of clinical development, medical affairs, biostatistics, commercial, and regulatory personnel. Dr. Talluri’s insight into clinical development and safety management comes not just from her work with pharmaceutical and biotech companies but also from her experience working with CROs, from pre–clinical to Phase I through Phase IV trials, covering the entire spectrum of activities in bringing a product to market and managing safety. She has several publications to her credit in leading medical journals. In addition to her experience in the pharmaceutical and biotech industries, Dr. Talluri has practiced general medicine and emergency medicine in India and the Caribbean, and psychiatry in the US. She completed her residency in Psychiatry at Duke University Medical Center.
David M. Eckmann, PhD, MD, is the Horatio C. Wood Professor of Anesthesiology and Critical Care and Professor of Bioengineering and Mechanical Engineering and Applied Mechanics at the University of Pennsylvania. He is a member of PENN's Institute for Medicine and Engineering, the Cardiovascular Institute, and a Founding Member of the Institute for Translational Medicine and Therapeutics. Dr. Eckmann is American Board of Anesthesiology certified with expertise in cardiopulmonary physiology, monitoring devices, and biofluid dynamics. His basic science research interests include research techniques in physiology, pharmacology, intravital microscopy, experimental fluid mechanics, and mathematical modeling related to blood and interfacial fluid dynamics, vascular biology, cellular mechanics and cellular bioenergetics and nanoparticle design for targeted drug delivery. Dr. Eckmann has over 20 years of continuous extramural grant funding, including serving as the principle investigator on multiple NIH, NSF, Department of Defense and NASA grants. He has also served an external consultant reviewer for the United States National Space Biomedical Research Institute.
Richard T. Mahon, MD has been a Pulmonary and Critical Care physician for 20 years and currently practices in the Maryland area. Dr. Mahon retired from the United States Navy where he served in Afghanistan as a critical care physician. Dr. Mahon demonstrated a mortality benefit in treating decompression sickness with perfluorocarbons (PFC) in a large animal model as well as showing a benefit with PFCs in spinal cord injury. Other areas of PFC investigation have included hemorrhage and acute respiratory distress syndrome.  His current research interests include decompression sickness, drowning and high altitude performance.